Aβ generation in autophagic vacuoles

نویسنده

  • Noboru Mizushima
چکیده

Alzheimer's disease (AD) is the most common form of dementia among older people. It is characterized by the extracellular accumulation of beta-amyloid (Abeta) deposits called senile or neuritic plaques. Abeta is generated by the proteolytic cleavage of Abeta precursor protein (APP) by beta and gamma-secretases localized in the secretory and endocytic compartments. In this issue, Yu et al. (on p. 87) report a novel mechanism for the generation of Abeta peptides, which takes place in autophagic vacuoles (AVs) that accumulate in AD brains.

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عنوان ژورنال:
  • The Journal of Cell Biology

دوره 171  شماره 

صفحات  -

تاریخ انتشار 2005